How to correctly choose API extraction equipment and process
Source ：QuanhuiBiology Add Time ： 2015-08-20 PV ：
Extract (leaching), also known as leaching, leaching, leaching, solid-liquid extraction. With dip or chemical reagents solid materials, to extract the useful component. It is a kind of all generation unit operation process. According to the different solid materials or plant (ore), there are physical leaching, chemical leaching or biological leaching. Physics leaching is a kind of simple dissolution process, the useful components of soluble in water, alcohol, or other organic solvent process. Chemical leaching in acid and alkali solution soluble compounds are formed by chemical reaction to make useful components and dissolved. Is generally used in hydrometallurgy, biological leaching with some sulfur bacteria oxidation treatment of sulfide mineral, also called bacterial leaching. In traditional Chinese medicine extraction is physics leaching in the process of raw material to produce a dissolving process, is the main equipment for the production of active pharmaceutical ingredients, how to choose the right? In many domestic experts have discussed, here I also want to put my point of view; A, process requirements: equipment is in the service of the process, select equipment must first meet the technological requirements; 1, technological requirements: we choose our equipment first consider its versatility, not a single; To adapt to the state (traditional), to adapt to The Times development (double pot hot reflux), the extraction of can adapt to a variety of process requirements (reflux, diacolation, dynamic cycle, etc.). ① Conventional extraction generally adopt the intermittent, able to adapt to a variety of different extraction solvent. ② Dynamic extraction has a variety of ways, can undertake choosing according to the technological requirements: stirring, hot reflux, outside circulation, reverse flow, etc.; 2、Production capacity requirements: ① Equipment volume choice: according to the properties of the material (leafy, roots, etc.) and solvent ratio choose the effective volume of extraction tank; What is the effective volume? From the tank is below 50 mm head starts calculating the position of the effective volume of equipment. Consider medicinal materials after water absorption expansion cannot block header pipe, adequate space shall be maintained. ② Equipment structure's choice: to consider the produced liquid and sludge discharge (some material properties cannot be at the bottom of the liquid, need reflux circulation and fluid), choosing structure considering the following aspects: A simple operation, low labor intensity, depending on the structure of feeding and the structure of the liquid slag)； bNo dead Angle, warming faster heating (depending on the form of heating, heating area)； cComplete, high efficiency (depending on the overall structure) The structure is out of reach for conventional extraction equipment. Refer to extract structure comparison chart Second, the production requirements: high efficiency, energy saving, easy operation, good safety; 1, high efficiency, can short time, no dead Angle to effectively extract extracted completely, residue emissions without residual; 2、Energy saving: through different means of heating () at the bottom of the jacket or heated conversion, efficient use of energy is extracted, without a lot of steam, a lot of condensing cooling circulation waste of energy; 3、Is simple: to reduce the intensity of labor is a basic requirement of equipment, such as liquid, slag difficulties will occupy the time spent working hours of labor, big also invisible increases the cost of production. 4、Security: is the production of primary consideration, for production and abnormal production of unsafe factors to effectively avoid and guard against Three, choose: generally choose tend to focus on the physical equipment, namely the price and appearance, and ignore the intangible, namely, safety and high efficiency and energy saving. For example; Operation of steam energy saving rate; Extract extraction yield; Solvent usage, etc.; Increase one percent can bring great benefits, which is often neglected. 1, price: different structure has different cost, equipment prices mainly by production costs (the cost of materials, plant and equipment depreciation, water and electricity supplies, manufacturing cost, etc.) management fees, taxes, fees, etc. Equipment making the cost of materials is straightforward: materials, product parts, mechanical parts, consumables, etc. General with equipment and the weight of the market price of main material can estimate. Have size mostly focus on cost management of enterprise, users understand is not very hard. 2, price: the current domestic extraction are many ways, there are intermittent and continuous. Continuous extraction, rarely on the market basically is the traditional process determines the extraction industry status quo. Intermittent way with conventional and modern, the structure is divided into mushroom type, cone type, straight cylinder, through structure than it can be seen that the ratio of extraction structure (see chart). 3、Maintenance rate: maintenance rate is also a factor of production cost. Pressure vessel annual check-up, wearing parts, consumable, pipe valves, etc.
